Wondonins A and B, two alkaloids of an unprecedented structural class, along with the previously described dihydroxystyryl sulfates, have been isolated from an association of the sponges Poecillastra wondoensis and Jaspis sp. collected from Keomun Island, Korea. The structures of these compounds have been determined as imidazole alkaloids containing a bis(dihydroxystyrene) moiety by combined spectroscopic methods. The new compounds exhibited antiangiogenic activity against human umbilical vein endothelial cells.
Bibliographical noteFunding Information:
Mass spectral data were kindly provided by Dr. Young Hwan Kim, Korea Basic Science Institute, Taejeon, Korea. Special thanks go to Ms. Sarah Chung, Mi-Sun Oh, and Kyoung Hwa Jang for assistance with the laboratory work. This research was financially supported by Ministry of Science and Technology (Grants PN-99384 and -00410).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry