Wondonins A and B, new bis(dihydroxystyryl)imidazoles from a two-sponge association

Jongheon Shin; Jung Rae Rho; Youngwan Seo; Hyi Seung Lee; Ki Woong Cho; Ho Jeong Kwon; Chung J. Sim

doi:10.1016/S0040-4039(01)00092-2

Wondonins A and B, new bis(dihydroxystyryl)imidazoles from a two-sponge association

Jongheon Shin, Jung Rae Rho, Youngwan Seo, Hyi Seung Lee, Ki Woong Cho, Ho Jeong Kwon, Chung J. Sim

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Wondonins A and B, two alkaloids of an unprecedented structural class, along with the previously described dihydroxystyryl sulfates, have been isolated from an association of the sponges Poecillastra wondoensis and Jaspis sp. collected from Keomun Island, Korea. The structures of these compounds have been determined as imidazole alkaloids containing a bis(dihydroxystyrene) moiety by combined spectroscopic methods. The new compounds exhibited antiangiogenic activity against human umbilical vein endothelial cells.

Original language	English
Pages (from-to)	1965-1968
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	10
DOIs	https://doi.org/10.1016/S0040-4039(01)00092-2
Publication status	Published - 2001 Mar 4

Bibliographical note

Funding Information:
Mass spectral data were kindly provided by Dr. Young Hwan Kim, Korea Basic Science Institute, Taejeon, Korea. Special thanks go to Ms. Sarah Chung, Mi-Sun Oh, and Kyoung Hwa Jang for assistance with the laboratory work. This research was financially supported by Ministry of Science and Technology (Grants PN-99384 and -00410).

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)00092-2

Cite this

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title = "Wondonins A and B, new bis(dihydroxystyryl)imidazoles from a two-sponge association",

abstract = "Wondonins A and B, two alkaloids of an unprecedented structural class, along with the previously described dihydroxystyryl sulfates, have been isolated from an association of the sponges Poecillastra wondoensis and Jaspis sp. collected from Keomun Island, Korea. The structures of these compounds have been determined as imidazole alkaloids containing a bis(dihydroxystyrene) moiety by combined spectroscopic methods. The new compounds exhibited antiangiogenic activity against human umbilical vein endothelial cells.",

author = "Jongheon Shin and Rho, {Jung Rae} and Youngwan Seo and Lee, {Hyi Seung} and Cho, {Ki Woong} and Kwon, {Ho Jeong} and Sim, {Chung J.}",

note = "Funding Information: Mass spectral data were kindly provided by Dr. Young Hwan Kim, Korea Basic Science Institute, Taejeon, Korea. Special thanks go to Ms. Sarah Chung, Mi-Sun Oh, and Kyoung Hwa Jang for assistance with the laboratory work. This research was financially supported by Ministry of Science and Technology (Grants PN-99384 and -00410).",

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T1 - Wondonins A and B, new bis(dihydroxystyryl)imidazoles from a two-sponge association

AU - Shin, Jongheon

AU - Rho, Jung Rae

AU - Seo, Youngwan

AU - Lee, Hyi Seung

AU - Cho, Ki Woong

AU - Kwon, Ho Jeong

AU - Sim, Chung J.

N1 - Funding Information: Mass spectral data were kindly provided by Dr. Young Hwan Kim, Korea Basic Science Institute, Taejeon, Korea. Special thanks go to Ms. Sarah Chung, Mi-Sun Oh, and Kyoung Hwa Jang for assistance with the laboratory work. This research was financially supported by Ministry of Science and Technology (Grants PN-99384 and -00410).

PY - 2001/3/4

Y1 - 2001/3/4

N2 - Wondonins A and B, two alkaloids of an unprecedented structural class, along with the previously described dihydroxystyryl sulfates, have been isolated from an association of the sponges Poecillastra wondoensis and Jaspis sp. collected from Keomun Island, Korea. The structures of these compounds have been determined as imidazole alkaloids containing a bis(dihydroxystyrene) moiety by combined spectroscopic methods. The new compounds exhibited antiangiogenic activity against human umbilical vein endothelial cells.

AB - Wondonins A and B, two alkaloids of an unprecedented structural class, along with the previously described dihydroxystyryl sulfates, have been isolated from an association of the sponges Poecillastra wondoensis and Jaspis sp. collected from Keomun Island, Korea. The structures of these compounds have been determined as imidazole alkaloids containing a bis(dihydroxystyrene) moiety by combined spectroscopic methods. The new compounds exhibited antiangiogenic activity against human umbilical vein endothelial cells.

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JO - Tetrahedron Letters

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Wondonins A and B, new bis(dihydroxystyryl)imidazoles from a two-sponge association

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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