Wound healing mechanism in Mongolian gerbil skin

Min Jung Lee, Dong Joon Lee, Han Sung Jung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). However, in the wound healing of gerbil skin, the expression of TGF-β1 seems to be not enough compared to mouse. In this study, we compared the wound healing process of gerbil and mouse back skin. At 3 days after wounding, the TGF-β1 level was downregulated in gerbil skin wound healing compared mouse. In addition, gerbils have fewer integrin signals related to the regulation of TGF-β activation and signaling. Despite lacking these factors, the wound healing results in the gerbil are similar to those for skin wound healing in mice. In contrast, in gerbil skin wound healing, the basal skin layer showed hyperplasia in re-epithelialization, more production of hair follicles, and low probability of collagen infiltration at the late stages of wound healing. These data suggest that different wound healing mechanisms are present in the mammals.

Original languageEnglish
Pages (from-to)229-238
Number of pages10
JournalHistochemistry and cell biology
Volume151
Issue number3
DOIs
Publication statusPublished - 2019 Mar 5

Fingerprint

Gerbillinae
Wound Healing
Skin
Transforming Growth Factor beta
Re-Epithelialization
Hair Follicle
Integrins
Hyperplasia
Mammals
Collagen
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

Cite this

Lee, Min Jung ; Lee, Dong Joon ; Jung, Han Sung. / Wound healing mechanism in Mongolian gerbil skin. In: Histochemistry and cell biology. 2019 ; Vol. 151, No. 3. pp. 229-238.
@article{bc270492d0cb4080bec5c7650d046d9a,
title = "Wound healing mechanism in Mongolian gerbil skin",
abstract = "The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). However, in the wound healing of gerbil skin, the expression of TGF-β1 seems to be not enough compared to mouse. In this study, we compared the wound healing process of gerbil and mouse back skin. At 3 days after wounding, the TGF-β1 level was downregulated in gerbil skin wound healing compared mouse. In addition, gerbils have fewer integrin signals related to the regulation of TGF-β activation and signaling. Despite lacking these factors, the wound healing results in the gerbil are similar to those for skin wound healing in mice. In contrast, in gerbil skin wound healing, the basal skin layer showed hyperplasia in re-epithelialization, more production of hair follicles, and low probability of collagen infiltration at the late stages of wound healing. These data suggest that different wound healing mechanisms are present in the mammals.",
author = "Lee, {Min Jung} and Lee, {Dong Joon} and Jung, {Han Sung}",
year = "2019",
month = "3",
day = "5",
doi = "10.1007/s00418-018-1752-z",
language = "English",
volume = "151",
pages = "229--238",
journal = "Histochemistry and Cell Biology",
issn = "0948-6143",
publisher = "Springer Verlag",
number = "3",

}

Wound healing mechanism in Mongolian gerbil skin. / Lee, Min Jung; Lee, Dong Joon; Jung, Han Sung.

In: Histochemistry and cell biology, Vol. 151, No. 3, 05.03.2019, p. 229-238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Wound healing mechanism in Mongolian gerbil skin

AU - Lee, Min Jung

AU - Lee, Dong Joon

AU - Jung, Han Sung

PY - 2019/3/5

Y1 - 2019/3/5

N2 - The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). However, in the wound healing of gerbil skin, the expression of TGF-β1 seems to be not enough compared to mouse. In this study, we compared the wound healing process of gerbil and mouse back skin. At 3 days after wounding, the TGF-β1 level was downregulated in gerbil skin wound healing compared mouse. In addition, gerbils have fewer integrin signals related to the regulation of TGF-β activation and signaling. Despite lacking these factors, the wound healing results in the gerbil are similar to those for skin wound healing in mice. In contrast, in gerbil skin wound healing, the basal skin layer showed hyperplasia in re-epithelialization, more production of hair follicles, and low probability of collagen infiltration at the late stages of wound healing. These data suggest that different wound healing mechanisms are present in the mammals.

AB - The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). However, in the wound healing of gerbil skin, the expression of TGF-β1 seems to be not enough compared to mouse. In this study, we compared the wound healing process of gerbil and mouse back skin. At 3 days after wounding, the TGF-β1 level was downregulated in gerbil skin wound healing compared mouse. In addition, gerbils have fewer integrin signals related to the regulation of TGF-β activation and signaling. Despite lacking these factors, the wound healing results in the gerbil are similar to those for skin wound healing in mice. In contrast, in gerbil skin wound healing, the basal skin layer showed hyperplasia in re-epithelialization, more production of hair follicles, and low probability of collagen infiltration at the late stages of wound healing. These data suggest that different wound healing mechanisms are present in the mammals.

UR - http://www.scopus.com/inward/record.url?scp=85055981827&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055981827&partnerID=8YFLogxK

U2 - 10.1007/s00418-018-1752-z

DO - 10.1007/s00418-018-1752-z

M3 - Article

C2 - 30392058

AN - SCOPUS:85055981827

VL - 151

SP - 229

EP - 238

JO - Histochemistry and Cell Biology

JF - Histochemistry and Cell Biology

SN - 0948-6143

IS - 3

ER -