Wound healing mechanism in Mongolian gerbil skin

Min Jung Lee, Dong Joon Lee, Han Sung Jung

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The skin wound healing ability of animals differs depending on the environment. The gerbil wound model showed a different wound healing mechanism than was known thus far. Many other wound healing mechanisms have been found to involve transforming growth factor-beta 1 (TGF-β1). However, in the wound healing of gerbil skin, the expression of TGF-β1 seems to be not enough compared to mouse. In this study, we compared the wound healing process of gerbil and mouse back skin. At 3 days after wounding, the TGF-β1 level was downregulated in gerbil skin wound healing compared mouse. In addition, gerbils have fewer integrin signals related to the regulation of TGF-β activation and signaling. Despite lacking these factors, the wound healing results in the gerbil are similar to those for skin wound healing in mice. In contrast, in gerbil skin wound healing, the basal skin layer showed hyperplasia in re-epithelialization, more production of hair follicles, and low probability of collagen infiltration at the late stages of wound healing. These data suggest that different wound healing mechanisms are present in the mammals.

Original languageEnglish
Pages (from-to)229-238
Number of pages10
JournalHistochemistry and cell biology
Volume151
Issue number3
DOIs
Publication statusPublished - 2019 Mar 5

Bibliographical note

Funding Information:
Acknowledgements This research was financially supported by grants from the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (NRF-2017M3A9B3061833).

All Science Journal Classification (ASJC) codes

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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