Xanthogranulomatous mastitis: Clinicopathology and pathological implications

JaSeung Koo, Woohee Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Xanthogranulomatous inflammation is an uncommon finding in the breast. Sixteen cases of xanthogranulomatous mastitis were reviewed to determine the characteristic clinicopathological features. Xanthogranulomatous mastitis involved foamy histiocyte clusters interspersed with inflammatory cells. Foamy histiocytes were bland with small pyknotic nuclei. Xanthogranulomatous mastitis was associated with fat necrosis in five cases (31%), multinucleated giant-cell reactions in six cases (38%), and cholesterol crystals in five cases (31%). In three cases (19%), xanthogranulomatous mastitis coincided with ductal carcinoma in situ or invasive ductal carcinoma. Duct ectasia with foamy histiocyte aggregates were noted in five cases (31%). It is suggested that the etiology of xanthogranulomatous mastitis is obstruction and rupture of the ectatic duct with foamy histiocyte aggregates. In breast core biopsy, granular cell tumor and invasive carcinoma such as histiocytoid carcinoma and lipid-rich carcinoma could demonstrate similar pathological features to xanthogranulomatous mastitis. In conclusion, xanthogranulomatous mastitis could be encountered in breast core biopsy and surgical excision tissue. Diagnosis of xanthogranulomatous mastitis can be made by excluding other diseases that elicit xanthogranulomatous inflammation in the breast. In breast core biopsy, xanthogranulomatous mastitis could be distinguished from granular cell tumor, histiocytoid carcinoma and lipid-rich carcinoma by using cytokeratin and histiocytic marker such as α1-anti-trypsin and CD68 stain.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalPathology International
Volume59
Issue number4
DOIs
Publication statusPublished - 2009 Apr 1

Fingerprint

Mastitis
Histiocytes
Breast
Carcinoma
Granular Cell Tumor
Biopsy
Fat Necrosis
Inflammation
Lipids
Pathologic Dilatations
Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Giant Cells
Keratins
Trypsin
Rupture
Coloring Agents
Cholesterol

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

@article{ea44b801e1f34714bfb2762b0a5f0e71,
title = "Xanthogranulomatous mastitis: Clinicopathology and pathological implications",
abstract = "Xanthogranulomatous inflammation is an uncommon finding in the breast. Sixteen cases of xanthogranulomatous mastitis were reviewed to determine the characteristic clinicopathological features. Xanthogranulomatous mastitis involved foamy histiocyte clusters interspersed with inflammatory cells. Foamy histiocytes were bland with small pyknotic nuclei. Xanthogranulomatous mastitis was associated with fat necrosis in five cases (31{\%}), multinucleated giant-cell reactions in six cases (38{\%}), and cholesterol crystals in five cases (31{\%}). In three cases (19{\%}), xanthogranulomatous mastitis coincided with ductal carcinoma in situ or invasive ductal carcinoma. Duct ectasia with foamy histiocyte aggregates were noted in five cases (31{\%}). It is suggested that the etiology of xanthogranulomatous mastitis is obstruction and rupture of the ectatic duct with foamy histiocyte aggregates. In breast core biopsy, granular cell tumor and invasive carcinoma such as histiocytoid carcinoma and lipid-rich carcinoma could demonstrate similar pathological features to xanthogranulomatous mastitis. In conclusion, xanthogranulomatous mastitis could be encountered in breast core biopsy and surgical excision tissue. Diagnosis of xanthogranulomatous mastitis can be made by excluding other diseases that elicit xanthogranulomatous inflammation in the breast. In breast core biopsy, xanthogranulomatous mastitis could be distinguished from granular cell tumor, histiocytoid carcinoma and lipid-rich carcinoma by using cytokeratin and histiocytic marker such as α1-anti-trypsin and CD68 stain.",
author = "JaSeung Koo and Woohee Jung",
year = "2009",
month = "4",
day = "1",
doi = "10.1111/j.1440-1827.2009.02356.x",
language = "English",
volume = "59",
pages = "234--240",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "4",

}

Xanthogranulomatous mastitis : Clinicopathology and pathological implications. / Koo, JaSeung; Jung, Woohee.

In: Pathology International, Vol. 59, No. 4, 01.04.2009, p. 234-240.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Xanthogranulomatous mastitis

T2 - Clinicopathology and pathological implications

AU - Koo, JaSeung

AU - Jung, Woohee

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Xanthogranulomatous inflammation is an uncommon finding in the breast. Sixteen cases of xanthogranulomatous mastitis were reviewed to determine the characteristic clinicopathological features. Xanthogranulomatous mastitis involved foamy histiocyte clusters interspersed with inflammatory cells. Foamy histiocytes were bland with small pyknotic nuclei. Xanthogranulomatous mastitis was associated with fat necrosis in five cases (31%), multinucleated giant-cell reactions in six cases (38%), and cholesterol crystals in five cases (31%). In three cases (19%), xanthogranulomatous mastitis coincided with ductal carcinoma in situ or invasive ductal carcinoma. Duct ectasia with foamy histiocyte aggregates were noted in five cases (31%). It is suggested that the etiology of xanthogranulomatous mastitis is obstruction and rupture of the ectatic duct with foamy histiocyte aggregates. In breast core biopsy, granular cell tumor and invasive carcinoma such as histiocytoid carcinoma and lipid-rich carcinoma could demonstrate similar pathological features to xanthogranulomatous mastitis. In conclusion, xanthogranulomatous mastitis could be encountered in breast core biopsy and surgical excision tissue. Diagnosis of xanthogranulomatous mastitis can be made by excluding other diseases that elicit xanthogranulomatous inflammation in the breast. In breast core biopsy, xanthogranulomatous mastitis could be distinguished from granular cell tumor, histiocytoid carcinoma and lipid-rich carcinoma by using cytokeratin and histiocytic marker such as α1-anti-trypsin and CD68 stain.

AB - Xanthogranulomatous inflammation is an uncommon finding in the breast. Sixteen cases of xanthogranulomatous mastitis were reviewed to determine the characteristic clinicopathological features. Xanthogranulomatous mastitis involved foamy histiocyte clusters interspersed with inflammatory cells. Foamy histiocytes were bland with small pyknotic nuclei. Xanthogranulomatous mastitis was associated with fat necrosis in five cases (31%), multinucleated giant-cell reactions in six cases (38%), and cholesterol crystals in five cases (31%). In three cases (19%), xanthogranulomatous mastitis coincided with ductal carcinoma in situ or invasive ductal carcinoma. Duct ectasia with foamy histiocyte aggregates were noted in five cases (31%). It is suggested that the etiology of xanthogranulomatous mastitis is obstruction and rupture of the ectatic duct with foamy histiocyte aggregates. In breast core biopsy, granular cell tumor and invasive carcinoma such as histiocytoid carcinoma and lipid-rich carcinoma could demonstrate similar pathological features to xanthogranulomatous mastitis. In conclusion, xanthogranulomatous mastitis could be encountered in breast core biopsy and surgical excision tissue. Diagnosis of xanthogranulomatous mastitis can be made by excluding other diseases that elicit xanthogranulomatous inflammation in the breast. In breast core biopsy, xanthogranulomatous mastitis could be distinguished from granular cell tumor, histiocytoid carcinoma and lipid-rich carcinoma by using cytokeratin and histiocytic marker such as α1-anti-trypsin and CD68 stain.

UR - http://www.scopus.com/inward/record.url?scp=63849158555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63849158555&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2009.02356.x

DO - 10.1111/j.1440-1827.2009.02356.x

M3 - Article

C2 - 19351366

AN - SCOPUS:63849158555

VL - 59

SP - 234

EP - 240

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 4

ER -