TY - JOUR
T1 - Yonsei criteria, a potential linkage to intratumoral Foxp3+/CD8+ ratio for the prediction of oncologic outcomes in resected left-sided pancreatic cancer
AU - Hwang, Ho Kyoung
AU - Lee, Sung Hwan
AU - Kim, Hyoung Il
AU - Kim, Se Hoon
AU - Choi, Junjeong
AU - Kang, Chang Moo
AU - Lee, Woo Jung
N1 - Funding Information:
This study was supported by a faculty research grant from Yonsei University College of Medicine for 2015 (6-2015-0162).
PY - 2020
Y1 - 2020
N2 - Purpose: This study sought to investigate associations among Yonsei criteria (tumor confined to the pancreas, intact fascia layer between the distal pancreas and the left adrenal gland and kidney, and tumor located more than 1-2 cm from the celiac axis) and tumor infiltrating lymphocytes in pancreatic cancer. Materials and Methods: Patients who underwent curative distal pancreatectomy due to left-sided pancreatic cancer from January 2000 to December 2011 were enrolled. Follow-up was completed September 30, 2015. Results: Fifty patients were enrolled. Having ≥ two metastatic lymph nodes (LNs, p=0.002), intraoperative transfusion (p=0.011), low levels of tumor infiltrating CD8+ T-cells (p=0.001), and a high Foxp3+/CD8+ ratio (p=0.009) were independent risk factors for disease-free survival. Not satisfying the Yonsei criteria (p=0.021), having ≥ two metastatic LNs (p=0.032), low levels of tumor infil- trating CD8+ T-cells (p=0.040) and a high Foxp3+/CD8+ ratio (p=0.032) were associated with unfavorable overall survival. High lev- els of CA19-9 and not satisfying the Yonsei criteria were significantly associated with a high Foxp3+/CD8+ ratio [Exp(β)=3.558; 95% confidence inverval: 1.000-12.658; p=0.050]. Conclusion: Yonsei criteria may be clinically detectable biologic marker with which to predict immunologic status and survival in pancreatic cancer patients.
AB - Purpose: This study sought to investigate associations among Yonsei criteria (tumor confined to the pancreas, intact fascia layer between the distal pancreas and the left adrenal gland and kidney, and tumor located more than 1-2 cm from the celiac axis) and tumor infiltrating lymphocytes in pancreatic cancer. Materials and Methods: Patients who underwent curative distal pancreatectomy due to left-sided pancreatic cancer from January 2000 to December 2011 were enrolled. Follow-up was completed September 30, 2015. Results: Fifty patients were enrolled. Having ≥ two metastatic lymph nodes (LNs, p=0.002), intraoperative transfusion (p=0.011), low levels of tumor infiltrating CD8+ T-cells (p=0.001), and a high Foxp3+/CD8+ ratio (p=0.009) were independent risk factors for disease-free survival. Not satisfying the Yonsei criteria (p=0.021), having ≥ two metastatic LNs (p=0.032), low levels of tumor infil- trating CD8+ T-cells (p=0.040) and a high Foxp3+/CD8+ ratio (p=0.032) were associated with unfavorable overall survival. High lev- els of CA19-9 and not satisfying the Yonsei criteria were significantly associated with a high Foxp3+/CD8+ ratio [Exp(β)=3.558; 95% confidence inverval: 1.000-12.658; p=0.050]. Conclusion: Yonsei criteria may be clinically detectable biologic marker with which to predict immunologic status and survival in pancreatic cancer patients.
UR - http://www.scopus.com/inward/record.url?scp=85082792028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082792028&partnerID=8YFLogxK
U2 - 10.3349/ymj.2020.61.4.291
DO - 10.3349/ymj.2020.61.4.291
M3 - Article
C2 - 32233171
AN - SCOPUS:85082792028
VL - 61
SP - 291
EP - 300
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
SN - 0513-5796
IS - 4
ER -