Yonsei Stroke Registry: Analysis of 1,000 patients with acute cerebral infarctions

Byung In Lee, Hyo Suk Nam, Ji Hoe Heo, Dong Ik Kim, Young Ho Shon, Seung Min Kim, Soo Chul Park, Jin Soo Kim, Il Sang Choi, Il Nam Sunwoo, Gyung Whan Kim, Chul Hee Choi, Pil Hyu Lee, Sun Ah Choi, Dong Chul Park, Kyung Yul Lee, Sang Won Han, Kyu Sik Kim, Bum Cheon Suh, Yun Kyung ChungPyung Ho Yoon, Jin Ill Chun

Research output: Contribution to journalArticle

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Abstract

Background and Purpose: The hospital-based stroke registry is a well-established method useful for understanding diverse clinical characteristics of stroke related to geographical, racial or environmental differences. We analyzed the data from 1,000 patients with acute cerebral infarctions registered with the Yonsei Stroke Registry (YSR) which is the first prospective hospital-based observational study in Korea. Methods: All patients had cerebral infarctions and presented within 7 days of onset. CT or MRI was performed in all patients and a vascular imaging study (digital subtraction or magnetic resonance angiography) was conducted in 53.9% of the patients. Subtype classification was made through a consensus approach based on the strict application of TOAST criteria. Results: The mean age of patients was 62 ± 12 years, and 60.8% were males. Undetermined cause (UD) was the most frequent subtype (40.6%), which was followed by lacunar stroke (LS 21.5%), cardiac embolism (CE 18.3%), large-artery atherosclerosis (LAA 16.5%) and other determined causes (3.1%). Hypertension was found in 64.3%, smoking in 35.2%, diabetes mellitus in 26.9%, hypercholesterolemia in 24.1%, high hematocrit (≥50%) in 21.8%, clinically identified potential cardiac sources of embolism in 18.3%, a history of previous stroke in 22.0% and a history of previous transient ischemic attack in 4.7%. Recurrent stroke was associated with a higher number of risk factors (p < 0.001) and a higher incidence of LAA (p =0.003) than the first stroke. Vertebrobasilar artery territorial infarction was found in 39.8%, which was associated with higher incidences of LAA and LS and a lower incidence of CE than carotid artery territorial lesions (p =0.001). The 30-day mortality rate was 5.3% and cerebral herniation caused early death in 52%. Conclusion: The distribution of stroke subtypes in the YSR was largely comparable with that of western registries. The highest incidence of UD might be related to the strict application of TOAST criteria.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalCerebrovascular Diseases
Volume12
Issue number3
DOIs
Publication statusPublished - 2001 Oct 27

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Cerebral Infarction
Registries
Stroke
Incidence
Embolism
Arteries
Lacunar Stroke
Magnetic Resonance Angiography
Transient Ischemic Attack
Korea
Hypercholesterolemia
Hematocrit
Carotid Arteries
Infarction
Observational Studies
Blood Vessels
Atherosclerosis
Consensus
Diabetes Mellitus
Smoking

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, B. I., Nam, H. S., Heo, J. H., Kim, D. I., Shon, Y. H., Kim, S. M., ... Chun, J. I. (2001). Yonsei Stroke Registry: Analysis of 1,000 patients with acute cerebral infarctions. Cerebrovascular Diseases, 12(3), 145-151. https://doi.org/10.1159/000047697
Lee, Byung In ; Nam, Hyo Suk ; Heo, Ji Hoe ; Kim, Dong Ik ; Shon, Young Ho ; Kim, Seung Min ; Park, Soo Chul ; Kim, Jin Soo ; Choi, Il Sang ; Sunwoo, Il Nam ; Kim, Gyung Whan ; Choi, Chul Hee ; Lee, Pil Hyu ; Choi, Sun Ah ; Park, Dong Chul ; Lee, Kyung Yul ; Han, Sang Won ; Kim, Kyu Sik ; Suh, Bum Cheon ; Chung, Yun Kyung ; Yoon, Pyung Ho ; Chun, Jin Ill. / Yonsei Stroke Registry : Analysis of 1,000 patients with acute cerebral infarctions. In: Cerebrovascular Diseases. 2001 ; Vol. 12, No. 3. pp. 145-151.
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abstract = "Background and Purpose: The hospital-based stroke registry is a well-established method useful for understanding diverse clinical characteristics of stroke related to geographical, racial or environmental differences. We analyzed the data from 1,000 patients with acute cerebral infarctions registered with the Yonsei Stroke Registry (YSR) which is the first prospective hospital-based observational study in Korea. Methods: All patients had cerebral infarctions and presented within 7 days of onset. CT or MRI was performed in all patients and a vascular imaging study (digital subtraction or magnetic resonance angiography) was conducted in 53.9{\%} of the patients. Subtype classification was made through a consensus approach based on the strict application of TOAST criteria. Results: The mean age of patients was 62 ± 12 years, and 60.8{\%} were males. Undetermined cause (UD) was the most frequent subtype (40.6{\%}), which was followed by lacunar stroke (LS 21.5{\%}), cardiac embolism (CE 18.3{\%}), large-artery atherosclerosis (LAA 16.5{\%}) and other determined causes (3.1{\%}). Hypertension was found in 64.3{\%}, smoking in 35.2{\%}, diabetes mellitus in 26.9{\%}, hypercholesterolemia in 24.1{\%}, high hematocrit (≥50{\%}) in 21.8{\%}, clinically identified potential cardiac sources of embolism in 18.3{\%}, a history of previous stroke in 22.0{\%} and a history of previous transient ischemic attack in 4.7{\%}. Recurrent stroke was associated with a higher number of risk factors (p < 0.001) and a higher incidence of LAA (p =0.003) than the first stroke. Vertebrobasilar artery territorial infarction was found in 39.8{\%}, which was associated with higher incidences of LAA and LS and a lower incidence of CE than carotid artery territorial lesions (p =0.001). The 30-day mortality rate was 5.3{\%} and cerebral herniation caused early death in 52{\%}. Conclusion: The distribution of stroke subtypes in the YSR was largely comparable with that of western registries. The highest incidence of UD might be related to the strict application of TOAST criteria.",
author = "Lee, {Byung In} and Nam, {Hyo Suk} and Heo, {Ji Hoe} and Kim, {Dong Ik} and Shon, {Young Ho} and Kim, {Seung Min} and Park, {Soo Chul} and Kim, {Jin Soo} and Choi, {Il Sang} and Sunwoo, {Il Nam} and Kim, {Gyung Whan} and Choi, {Chul Hee} and Lee, {Pil Hyu} and Choi, {Sun Ah} and Park, {Dong Chul} and Lee, {Kyung Yul} and Han, {Sang Won} and Kim, {Kyu Sik} and Suh, {Bum Cheon} and Chung, {Yun Kyung} and Yoon, {Pyung Ho} and Chun, {Jin Ill}",
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Lee, BI, Nam, HS, Heo, JH, Kim, DI, Shon, YH, Kim, SM, Park, SC, Kim, JS, Choi, IS, Sunwoo, IN, Kim, GW, Choi, CH, Lee, PH, Choi, SA, Park, DC, Lee, KY, Han, SW, Kim, KS, Suh, BC, Chung, YK, Yoon, PH & Chun, JI 2001, 'Yonsei Stroke Registry: Analysis of 1,000 patients with acute cerebral infarctions', Cerebrovascular Diseases, vol. 12, no. 3, pp. 145-151. https://doi.org/10.1159/000047697

Yonsei Stroke Registry : Analysis of 1,000 patients with acute cerebral infarctions. / Lee, Byung In; Nam, Hyo Suk; Heo, Ji Hoe; Kim, Dong Ik; Shon, Young Ho; Kim, Seung Min; Park, Soo Chul; Kim, Jin Soo; Choi, Il Sang; Sunwoo, Il Nam; Kim, Gyung Whan; Choi, Chul Hee; Lee, Pil Hyu; Choi, Sun Ah; Park, Dong Chul; Lee, Kyung Yul; Han, Sang Won; Kim, Kyu Sik; Suh, Bum Cheon; Chung, Yun Kyung; Yoon, Pyung Ho; Chun, Jin Ill.

In: Cerebrovascular Diseases, Vol. 12, No. 3, 27.10.2001, p. 145-151.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Yonsei Stroke Registry

T2 - Analysis of 1,000 patients with acute cerebral infarctions

AU - Lee, Byung In

AU - Nam, Hyo Suk

AU - Heo, Ji Hoe

AU - Kim, Dong Ik

AU - Shon, Young Ho

AU - Kim, Seung Min

AU - Park, Soo Chul

AU - Kim, Jin Soo

AU - Choi, Il Sang

AU - Sunwoo, Il Nam

AU - Kim, Gyung Whan

AU - Choi, Chul Hee

AU - Lee, Pil Hyu

AU - Choi, Sun Ah

AU - Park, Dong Chul

AU - Lee, Kyung Yul

AU - Han, Sang Won

AU - Kim, Kyu Sik

AU - Suh, Bum Cheon

AU - Chung, Yun Kyung

AU - Yoon, Pyung Ho

AU - Chun, Jin Ill

PY - 2001/10/27

Y1 - 2001/10/27

N2 - Background and Purpose: The hospital-based stroke registry is a well-established method useful for understanding diverse clinical characteristics of stroke related to geographical, racial or environmental differences. We analyzed the data from 1,000 patients with acute cerebral infarctions registered with the Yonsei Stroke Registry (YSR) which is the first prospective hospital-based observational study in Korea. Methods: All patients had cerebral infarctions and presented within 7 days of onset. CT or MRI was performed in all patients and a vascular imaging study (digital subtraction or magnetic resonance angiography) was conducted in 53.9% of the patients. Subtype classification was made through a consensus approach based on the strict application of TOAST criteria. Results: The mean age of patients was 62 ± 12 years, and 60.8% were males. Undetermined cause (UD) was the most frequent subtype (40.6%), which was followed by lacunar stroke (LS 21.5%), cardiac embolism (CE 18.3%), large-artery atherosclerosis (LAA 16.5%) and other determined causes (3.1%). Hypertension was found in 64.3%, smoking in 35.2%, diabetes mellitus in 26.9%, hypercholesterolemia in 24.1%, high hematocrit (≥50%) in 21.8%, clinically identified potential cardiac sources of embolism in 18.3%, a history of previous stroke in 22.0% and a history of previous transient ischemic attack in 4.7%. Recurrent stroke was associated with a higher number of risk factors (p < 0.001) and a higher incidence of LAA (p =0.003) than the first stroke. Vertebrobasilar artery territorial infarction was found in 39.8%, which was associated with higher incidences of LAA and LS and a lower incidence of CE than carotid artery territorial lesions (p =0.001). The 30-day mortality rate was 5.3% and cerebral herniation caused early death in 52%. Conclusion: The distribution of stroke subtypes in the YSR was largely comparable with that of western registries. The highest incidence of UD might be related to the strict application of TOAST criteria.

AB - Background and Purpose: The hospital-based stroke registry is a well-established method useful for understanding diverse clinical characteristics of stroke related to geographical, racial or environmental differences. We analyzed the data from 1,000 patients with acute cerebral infarctions registered with the Yonsei Stroke Registry (YSR) which is the first prospective hospital-based observational study in Korea. Methods: All patients had cerebral infarctions and presented within 7 days of onset. CT or MRI was performed in all patients and a vascular imaging study (digital subtraction or magnetic resonance angiography) was conducted in 53.9% of the patients. Subtype classification was made through a consensus approach based on the strict application of TOAST criteria. Results: The mean age of patients was 62 ± 12 years, and 60.8% were males. Undetermined cause (UD) was the most frequent subtype (40.6%), which was followed by lacunar stroke (LS 21.5%), cardiac embolism (CE 18.3%), large-artery atherosclerosis (LAA 16.5%) and other determined causes (3.1%). Hypertension was found in 64.3%, smoking in 35.2%, diabetes mellitus in 26.9%, hypercholesterolemia in 24.1%, high hematocrit (≥50%) in 21.8%, clinically identified potential cardiac sources of embolism in 18.3%, a history of previous stroke in 22.0% and a history of previous transient ischemic attack in 4.7%. Recurrent stroke was associated with a higher number of risk factors (p < 0.001) and a higher incidence of LAA (p =0.003) than the first stroke. Vertebrobasilar artery territorial infarction was found in 39.8%, which was associated with higher incidences of LAA and LS and a lower incidence of CE than carotid artery territorial lesions (p =0.001). The 30-day mortality rate was 5.3% and cerebral herniation caused early death in 52%. Conclusion: The distribution of stroke subtypes in the YSR was largely comparable with that of western registries. The highest incidence of UD might be related to the strict application of TOAST criteria.

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