YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25. I. Taxonomy, fermentation, isolation and characterization

Yong Sun Bahn, Jung Min Park, Dong Hoon Bai, Shigehiro Takase, Ju Hyun Yu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

YUA001 is a novel aldose reductase inhibitor produced from alkalophilic Corynebacterium sp. YUA25 isolated from soil. YUA001 was purified from the supernatant of culture broth by successive silica gel column chromatography, Sephadex LH20-100 gel column chromatography, and HPLC. From instrumental analysis, molecular formula of YUA001 is C13H19NO2 and its molecular weight is 221. It exhibits potent aldose reductase inhibition activity and has no antimicrobial activity against some Gram-positive or Gram-negative bacteria, fungi and yeast.

Original languageEnglish
Pages (from-to)902-907
Number of pages6
JournalJournal of Antibiotics
Volume51
Issue number10
DOIs
Publication statusPublished - 1998 Oct

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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