Uncontrollable release and unexpected release limit the use of nitric oxide (NO). To overcome this problem, we introduce ZIF-8 as a pH-responsive NO carrier. The flexible framework of ZIF-8 under the high-pressure condition causes the physically NO adsorption inside the SOD cage. ZIF-8 maintain the excellent gas storage ability under the physiological environment. The results show good pH-responsive ability. The gas could not be released out until the particle is in an acid condition. At low pH conditions, half of the gas is released in 1% of the total release duration. Interestingly, the half-release (t1/2) increases to 10% when the phosphate species exist in the acid surrounding. The gradual release can occur under neutral conditions with the existence of phosphate (t1/2 33%). From these results, we expect this ZIF-8 loading NO nanoparticles is lead to the design of innovative gas therapeutic delivery platforms using the advantage of the flexible framework for loading and releasing the gas molecule.
Bibliographical noteFunding Information:
The authors acknowledge the financial supports by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1E1A1A01074343 ). The Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT ( NRF-2016M3A9C6917405 , NRF-2019M3A9H110378611 ). Yonsei University Future-leading Research Initiative of 2018 ( RMS 2018-22-0049 ). This work was also supported by the 2020 Research Fund of the University of Seoul for Jong Bum Lee .
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)