Abstract
Uncontrollable release and unexpected release limit the use of nitric oxide (NO). To overcome this problem, we introduce ZIF-8 as a pH-responsive NO carrier. The flexible framework of ZIF-8 under the high-pressure condition causes the physically NO adsorption inside the SOD cage. ZIF-8 maintain the excellent gas storage ability under the physiological environment. The results show good pH-responsive ability. The gas could not be released out until the particle is in an acid condition. At low pH conditions, half of the gas is released in 1% of the total release duration. Interestingly, the half-release (t1/2) increases to 10% when the phosphate species exist in the acid surrounding. The gradual release can occur under neutral conditions with the existence of phosphate (t1/2 33%). From these results, we expect this ZIF-8 loading NO nanoparticles is lead to the design of innovative gas therapeutic delivery platforms using the advantage of the flexible framework for loading and releasing the gas molecule.
| Original language | English |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | Journal of Industrial and Engineering Chemistry |
| Volume | 91 |
| DOIs | |
| Publication status | Published - 2020 Nov 25 |
Bibliographical note
Funding Information:The authors acknowledge the financial supports by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1E1A1A01074343). The Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2016M3A9C6917405, NRF-2019M3A9H110378611). Yonsei University Future-leading Research Initiative of 2018 (RMS 2018-22-0049). This work was also supported by the 2020 Research Fund of the University of Seoul for Jong Bum Lee.
Funding Information:
The authors acknowledge the financial supports by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1E1A1A01074343 ). The Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT ( NRF-2016M3A9C6917405 , NRF-2019M3A9H110378611 ). Yonsei University Future-leading Research Initiative of 2018 ( RMS 2018-22-0049 ). This work was also supported by the 2020 Research Fund of the University of Seoul for Jong Bum Lee .
Publisher Copyright:
© 2020 The Korean Society of Industrial and Engineering Chemistry
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)