ZnO nanowire-based glucose biosensors with different coupling agents

Juneui Jung, Sangwoo Lim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

ZnO-nanowire-based glucose biosensors were fabricated by immobilizing glucose oxidase (GOx) onto a linker attached to ZnO nanowires. Different coupling agents were used, namely (3-aminopropyl)trimethoxysilane (APTMS), (3-aminopropyl)triethoxysilane (APTES), and (3-aminopropyl)methyldiethoxysilane (APS), to increase the affinity of GOx binding to ZnO nanowires. The amount of GOx immobilized on the ZnO nanowires, the performance, sensitivity, and Michaelis-Menten constant of each biosensor, and the electron transfer resistance through the biosensor were all measured in order to investigate the effect of the coupling agent on the ZnO nanowire-based biosensor. Among the different biosensors, the APS-treated biosensor had the highest sensitivity (17.72 μA cm -2 mM -1 ) and the lowest Michaelis-Menten constant (1.37 mM). Since APS-treated ZnO nanowires showed the largest number of CN groups and the lowest electron transfer resistance through the biosensor, we concluded that these properties were the key factors in the performance of APS-treated glucose biosensors.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalApplied Surface Science
Volume265
DOIs
Publication statusPublished - 2013 Jan 15

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Coupling agents
Biosensors
Nanowires
Glucose
Glucose Oxidase
Glucose oxidase
Electrons

All Science Journal Classification (ASJC) codes

  • Surfaces, Coatings and Films

Cite this

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ZnO nanowire-based glucose biosensors with different coupling agents. / Jung, Juneui; Lim, Sangwoo.

In: Applied Surface Science, Vol. 265, 15.01.2013, p. 24-29.

Research output: Contribution to journalArticle

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